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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » A » Abnormalities, Drug-Induced/embryology

Abnormalities, Drug-Induced/embryology

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1. Notable sequential alterations in notochord volume during development in the Adriamycin rat model

The aim of this study was to assess notochord volume sequentially from gestational days 10 to 14 to test the hypothesis that notochord hypertrophy occurs maximally soon after Adriamycin administration

Abstract:

BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the vertebral, anorectal, cardiac, tracheoesophageal, renal, and limb association. An important finding in the ARM is that Adriamycin induces abnormal notochord morphology in the region of the foregut. Having recently demonstrated notochord hypertrophy in ARM embryos, the authors designed this study to more...

Categories:

notochord volume; Adriamycin

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 40 Page: 403-6 February 2005
A. Mortell; J. Gillick; S. Giles; J. Bannigan; P. Puri

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