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Irish Child Health Database - Peer Reviewed Papers

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Notochord/ abnormalities/drug effects

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1. Notochord anomalies in the adriamycin rat model: A morphologic and molecular basis for the VACTERL association

The aim of this study was to test the hypothesize that notochord anomalies allow ectopic expression of molecular signals in the developing embryo and thus lead to VACTERL malformations

Abstract:

BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a reliable model of the VACTERL association. The notochord is structurally abnormal in the region of the foregut, midgut, and hindgut in the ARM. The authors hypothesised that notochord anomalies allow ectopic expression of molecular signals in the developing embryo and thus lead to VACTERL malformations. This study was designed to more...

Categories:

notochord anomalies; VACTERL malformations - Vertebral Anal Cardiac Fistula +/- eosophageal atresia : Renal or Radius Limb anomalies

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 38 Page: 469-73; discussion 469-73 March 2003
J. Gillick; E. Mooney; S. Giles; J. Bannigan; P. Puri

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