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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » P » Pulmonary Surfactants/ metabolism

Pulmonary Surfactants/ metabolism

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1. Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats

The aim of this study was to investigate whether maternal administration of dexamethasone has any effect on the expression of surfactant protein A and surfactant protein B in nitrofen-induced experimental congenital diaphragmatic hernia rat model

Abstract:

BACKGROUND/PURPOSE: Pulmonary hypoplasia is one of the main causes for the high mortality rate in patients with congenital diaphragmatic hernia (CDH). The expression of surfactant protein A in the hypoplastic CDH lung is reduced, and its concentration is decreased in the amniotic fluid of pregnancies complicated by CDH. In a CDH experimental model, prenatal glucocorticoid treatment has more...

Categories:

maternal administration of dexamethason; congenital diaphragmatic hernia

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 35 Page: 1468-73 October 2000
N. Guarino; T. Oue; H. Shima; P. Puri

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