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The aim of this study was to investigate the effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants
Abstract:
PURPOSE: Nitric oxide (NO) can accelerate branching morphogenesis of fetal rat lung explants in vitro, whereas its exact mechanism remains unclear. In this study, we investigate the effect of NO on the expression of fibroblast growth factor-10 (FGF10) and bone morphogenetic protein-4 (BMP4), which plays an important role in bud formation. METHODS: Fetal rat lungs harvested on day 13.5 more...
Categories:
nitric oxide; fibroblast growth factor-10; branching morphogenesis of the lung
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 1030-3 June 2005
M. Shinkai; T. Shinkai; M. A. Pirker; S. Montedonico; P. Puri
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The aim of this study was to evaluate the effect of nitric oxide on the morphogenesis of hypoplastic lung using nitrofen-induced rat lung explant model
Abstract:
BACKGROUND/PURPOSE: Nitric oxide (NO) is an important cell-signaling molecule, and its generators, nitric oxide synthases, are expressed temporospatially in fetal rat lung. Recently, NO has been reported to modulate branching of the fetal rat lung lobe in vitro. We designed this study to evaluate the effect of NO on the morphogenesis of hypoplastic lung using nitrofen-induced rat lung more...
Categories:
nitric oxide; hypoplastic lung
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 17-21 January 2005
M. Shinkai; T. Shinkai; M. E. Pirker; S. Montedonico; P. Puri
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