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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Proto-Oncogene Proteins c-ret

Your search returns 4 documents

• 1.   Glial-derived growth factor signaling pathway in infantile hypertrophic pyloric stenosis

  The aim of this study was to investigate the expression of glial-derived growth factor and RET in infantile hypertrophic pyloric stenosis

  

  Abstract:

  BACKGROUND/PURPOSE: Glial-derived growth factor (GDNF), which is the ligand of RET is reported to be essential for the development of enteric nervous system. A GDNF knockout mouse model has shown that the gastric region is a critical passing site between GDNF-RET-independent neuroblasts (colonizing the esophagus) and GDNF-RET-dependent neuroblasts (colonizing the small and large bowel). more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis

  Categories:

  glial-derived growth factor; -infantile hypertrophic pyloric stenosis

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 835-9 June 2000
  N. Guarino; H. Shima; T. Oue; P. Puri

  [Preview] [Read]

• 2.   Mutation analysis of the RET gene in total intestinal aganglionosis by wave DNA fragment analysis system

  The aim of this study was to examine DNA variants in the RET gene in total intestinal aganglionosis patients using the WAVE DNA Fragment Analysis System

  

  Abstract:

  BACKGROUND/PURPOSE: Total intestinal aganglionosis (TIA) extending from the duodenum to the rectum is the most rare form of Hirschprung's disease (HSCR) and usually is fatal. RET is the major gene associated with HSCR, and germline mutations of this gene account for up 50% of familial and up to 15 to 20% of sporadic cases in HSCR. The aim of this study was to investigate DNA variants in more...

  International Classification:

  Other - intestinal aganglionosis

  Categories:

  total intestinal aganglionosis

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 38 Page: 497-501 March 2003
  V. Solari; S. Ennis; A. Yoneda; L. Wong; A. Messineo; M. E. Hollwarth; A. Green; P. Puri

  [Preview] [Read]

• 3.   Pathogenesis of Hirschsprung's disease and its variants: recent progress

  The article discusses pathogenesis of Hirschsprung's disease and its variants: recent progress

  

  Abstract:

  The enteric nervous system (ENS) is a complex network of interconnected neurons within the wall of the intestine that controls intestinal motility, regulates mucosal secretion and blood flow, and also modulates sensation from the gut. The cells that form the ENS in mammals are derived primarily from vagal neural crest cells. During the past decade there has been an explosion of more...

  Geography:

  Republic of Ireland

  Semin Pediatr Surg, Vol: 13 Page: 18-24 February 2004
  P. Puri; T. Shinkai

  [Preview] [Read]

• 4.   Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma

  The aim of this study was to examine prevalence of the common ret chimeric transcripts (ret/PTC-1 and ret/PTC-3) in a group of sporadic proto-oncogene proteins and correlate them with tumour morphology

  

  Abstract:

  Ret rearrangements are common in papillary thyroid carcinoma (PTC), with ret/PTC-3 commonly seen in children exposed to ionizing radiation. In this context ret/PTC-3 has been correlated with solid variant morphology, poorer prognosis, and aggressive tumor behavior. We aimed to assess the prevalence of the common ret chimeric transcripts (ret/PTC-1 and ret/PTC-3) in a group of sporadic more...

  International Classification:

  Other - chimeric transcripts

  Categories:

  ret chimeric transcripts; Proto-Oncogene Proteins; ret chimeric transcripts

  Geography:

  Republic of Ireland

  J Clin Endocrinol Metab, Vol: 88 Page: 938-41 February 2003
  S. P. Finn; P. Smyth; J. O'Leary; E. C. Sweeney; O. Sheils

  [Preview] [Read]