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Irish Child Health Database - Peer Reviewed Papers

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Myocardium/ metabolism

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• 1.   Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats

  The aim of this study was to determine cardiac gene expression of ET-1 and of its receptor ET(A) and the cardiac ET-1 content in the heart of nitrofen-induced congenital diaphragmatic hernia in rats and evaluate antenatal Dexamethason treatment effects

  

  Abstract:

  BACKGROUND/PURPOSE: Although high levels of endothelin-1 (ET-1) in plasma may be relevant in certain pathophysiologic states, such as pulmonary hypertension accompanying congenital diaphragmatic hernia (CDH), experimental evidence favors a local, paracrine, or autocrine role for ET-1 in most tissues. Evidence of ET-1 production has been documented in fetal heart tissue where it exerts more...

  Categories:

  ET-1 and receptor ET(A) receptor; congenital diaphragmatic hernia;

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 37 Page: 1563-7 November 2002
  N. Guarino; P. Puri

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• 2.   Cardiac gene expression and synthesis of atrial natriuretic peptide in the nitrofen model of congenital diaphragmatic hernia in rats: effect of prenatal dexamethazone treatment

  The aim of this study was to determine the gene and protein levels of atrial natriuretic peptide in the heart of nitrofen-induced congenital diaphragmatic hernia in rats and to evaluate the effect of antenatal dexamethazone treatment

  

  Abstract:

  BACKGROUND/PURPOSE:The aim of this study was to determine the gene and protein levels of atrial natriuretic peptide (ANP) in the heart of nitrofen-induced congenital diaphragmatic hernia (CDH) in rats and to evaluate the effect of antenatal dexamethazone (Dex) treatment. METHODS: CDH model was induced in pregnant rats after administration of 100 mg of nitrofen on day 9.5 of gestation more...

  Categories:

  antenatal dexamethazone treatment; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 36 Page: 1497-501 October 2001
  N. Guarino; H. Shima; P. Puri

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