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Irish Child Health Database - Peer Reviewed Papers

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Myocardial Contraction/ drug effects

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1. Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats

The aim of this study was to determine cardiac gene expression of ET-1 and of its receptor ET(A) and the cardiac ET-1 content in the heart of nitrofen-induced congenital diaphragmatic hernia in rats and evaluate antenatal Dexamethason treatment effects

Abstract:

BACKGROUND/PURPOSE: Although high levels of endothelin-1 (ET-1) in plasma may be relevant in certain pathophysiologic states, such as pulmonary hypertension accompanying congenital diaphragmatic hernia (CDH), experimental evidence favors a local, paracrine, or autocrine role for ET-1 in most tissues. Evidence of ET-1 production has been documented in fetal heart tissue where it exerts more...

Categories:

ET-1 and receptor ET(A) receptor; congenital diaphragmatic hernia;

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 37 Page: 1563-7 November 2002
N. Guarino; P. Puri

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