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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Dexamethasone/ administration & dosage

Your search returns 4 documents

• 1.   Administration of antenatal glucocorticoids upregulates peptide growth factor gene expression in nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate antenatal glucocorticoids administration effect on gene expression of basic fibroblast growth factor, platelet-derived growth factor transforming growth factor-beta1 in congenital diaphragmatic hernia

  

  Abstract:

  BACKGROUND/PURPOSE: There is increasing evidence to suggest that various growth factors play a crucial role in fetal lung growth and morphogenesis. An array of peptide growth factors regulate cell proliferation, differentiation, and various other cell functions in the developing lung. The aim of this study was to investigate the effect of antenatal glucocorticoids administration on gene more...

  Categories:

  antenatal glucocorticoids administration; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 109-12 January 2000
  T. Oue; H. Shima; Y. Taira; P. Puri

  [Preview] [Read]

• 2.   Antenatal dexamethasone administration inhibits smooth-muscle-cell DNA synthesis in pulmonary-arterial media in nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate the effect of antenatal glucocorticoid therapy on smooth-muscle-cell DNA synthesis in the pulmonary arteries in a nitrofen-induced congenital diaphragmatic hernia rat model following nitrofen admin

  

  Abstract:

  The aim of this study was to investigate the effect of antenatal glucocorticoid therapy on smooth-muscle-cell (SMC) DNA synthesis in the pulmonary arteries (PA) in a nitrofen-induced congenital diaphragmatic hernia (CDH) rat model following nitrofen administration on day 9.5 of gestation. Antenatal dexamethasone (DEX) was given intraperitoneally on days 18.5 and 19.5 of gestation. more...

  Categories:

  antenatal glucocorticoid therapy; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 16 Page: 414-6 2000
  Y. Taira; H. Shima; E. Miyazaki; K. Ohshiro; P. Puri

  [Preview] [Read]

• 3.   Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats

  The aim of this study was to determine cardiac gene expression of ET-1 and of its receptor ET(A) and the cardiac ET-1 content in the heart of nitrofen-induced congenital diaphragmatic hernia in rats and evaluate antenatal Dexamethason treatment effects

  

  Abstract:

  BACKGROUND/PURPOSE: Although high levels of endothelin-1 (ET-1) in plasma may be relevant in certain pathophysiologic states, such as pulmonary hypertension accompanying congenital diaphragmatic hernia (CDH), experimental evidence favors a local, paracrine, or autocrine role for ET-1 in most tissues. Evidence of ET-1 production has been documented in fetal heart tissue where it exerts more...

  Categories:

  ET-1 and receptor ET(A) receptor; congenital diaphragmatic hernia;

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 37 Page: 1563-7 November 2002
  N. Guarino; P. Puri

  [Preview] [Read]

• 4.   Neurodevelopmental and respiratory follow-up results at 7 years for children from the United Kingdom and Ireland enrolled in a randomized trial of early and late postnatal corticosteroid treatment, systemic and inhaled (the Open Study of Early Corticosteroid Treatment)

  The aim of the study was to compare early school-age neurodevelopmental and respiratory outcomes for children treated with either early (<3/7) or delayed selective (>15/7) postnatal corticosteroid therapy comparing dexamethasone with budesonide treatment

  

  Abstract:

  OBJECTIVES: The goals were to compare early school-age neurodevelopmental and respiratory outcomes for children who were treated with either early (<3 days) or delayed selective (>15 days) postnatal corticosteroid therapy and to compare systemic dexamethasone treatment with inhaled budesonide treatment. METHODS: One hundred twenty-seven (84%) of 152 survivors from the United Kingdom and more...

  International Classification:

  Growth and development

  Categories:

  neurodevelopmental and respiratory outcomes

  Geography:

  Republic of Ireland and the United Kingdom

  Pediatrics, Vol: 117 Page: 2196-205 June 2006
  T. T. Wilson; L. Waters; C. C. Patterson; C. G. McCusker; N. M. Rooney; N. Marlow; H. L. Halliday

  [Preview] [Read]