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Irish Child Health Database - Peer Reviewed Papers

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Dexamethasone/ pharmacology

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• 1.   Antenatal dexamethasone enhances endothelin receptorB expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to evaluate the effect of antenatal glucocorticoid administration on ET-1 system in nitrofen-induced congenital diaphragmatic hernia hypoplastic lung in rats

  

  Abstract:

  BACKGROUND/PURPOSE: The hypoplastic lung and persistent pulmonary hypertension (PPH) are the principle causes of high mortality and morbidity in infants with congenital diaphragmatic hernia (CDH). Endothelin-1 (ET-1), which is produced by vascular endothelial cells and some leukocytes, plays a key role in modulating pulmonary vascular tone in PPH. Two different receptors (ET(A) and more...

  Categories:

  antenatal glucocorticoid; congenital diaphragmatic hernia lung

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 203-7 February 2000
  H. Shima; T. Oue; Y. Taira; E. Miyazaki; P. Puri

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• 2.   Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate whether maternal administration of dexamethasone has any effect on the expression of surfactant protein A and surfactant protein B in nitrofen-induced experimental congenital diaphragmatic hernia rat model

  

  Abstract:

  BACKGROUND/PURPOSE: Pulmonary hypoplasia is one of the main causes for the high mortality rate in patients with congenital diaphragmatic hernia (CDH). The expression of surfactant protein A in the hypoplastic CDH lung is reduced, and its concentration is decreased in the amniotic fluid of pregnancies complicated by CDH. In a CDH experimental model, prenatal glucocorticoid treatment has more...

  Categories:

  maternal administration of dexamethason; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 1468-73 October 2000
  N. Guarino; T. Oue; H. Shima; P. Puri

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• 3.   Antenatal dexamethasone improves atrial natriuretic peptide receptors in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate the effect of antenatal glucocorticoid administration on the atrial natriuretic peptide system in nitrofen-induced congenital diaphragmatic hernia hypoplastic lung in rats.

  

  Abstract:

  Atrial natriuretic peptide (ANP) plays a major role in electrolyte and volume homeostasis through potent biological effects including vasorelaxation, bronchorelaxation, lung permeability, and clearance. There are two distinct biochemical and functional classes of ANP receptors, guanylate cyclase receptor (GC-R) and clearance receptors (clearance-R). Two subtypes of GC-R have been more...

  Categories:

  antenatal glucocorticoid; atrial natriuretic peptide system; congenital diaphragmatic hernia hypoplastic lung

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 16 Page: 252-5 2000
  H. Shima; N. Guarino; P. Puri

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