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Irish Child Health Database - Peer Reviewed Papers

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Arthrogryposis/genetics/ veterinary

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1. Linkage mapping of the locus for inherited ovine arthrogryposis (IOA) to sheep chromosome 5

The aim of this study was to undertake a genome scan using 187 microsatellite genetic markers and all backcross animals were phenotyped at birth for the presence and severity of arthrogryposis

Abstract:

Arthrogryposis is a congenital malformation affecting the limbs of newborn animals and infants. Previous work has demonstrated that inherited ovine arthrogryposis (IOA) has an autosomal recessive mode of inheritance. Two affected homozygous recessive (art/art) Suffolk rams were used as founders for a backcross pedigree of half-sib families segregating the IOA trait. A genome scan was more...

Categories:

genome scan; genetic markers; arthrogryposis

Geography:

Republic of Ireland

Mamm Genome, Vol: 18 Page: 43-52 January 2007
A. M. Murphy; D. E. MacHugh; S. D. Park; E. Scraggs; C. S. Haley; D. J. Lynn; M. P. Boland; M. L. Doherty

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