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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » D » Dexamethasone/pharmacology/ therapeutic use

Dexamethasone/pharmacology/ therapeutic use

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1. Antenatal dexamethasone administration increases fetal lung DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia in rats

The aim of this study was to investigate the effect of antenatal glucocorticoid administration on DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia in rats

Abstract:

Antenatal glucocorticoids treatment has been shown to correct pulmonary immaturity. The thymidine analog bromodeoxyuridine (BrdU) is incorporated into S-phase cells and used as a marker of DNA synthesis. In this study, we investigated the effect of antenatal glucocorticoid administration on DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia more...

Categories:

antenatal glucocorticoid; DNA synthesis; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Res, Vol: 48 Page: 789-93 December 2000
T. Oue; H. Shima; N. Guarino; P. Puri

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