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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Antiretroviral Therapy, Highly Active

Your search returns 7 documents

• 1.   Antiretroviral therapy and congenital abnormalities in infants born to HIV-1-infected women in the United Kingdom and Ireland, 1990 to 2003

  The aim of this study was to describe antiretroviral therapy and congenital abnormalities in infants born to HIV-1-infected women

  

  Abstract:

  Antiretroviral therapy (ART) in pregnancy substantially reduces the risk of mother-to-child transmission of HIV, but concerns exist about the potential for teratogenic effects. This analysis was undertaken to explore the relation between ART in pregnancy and birth defects in infants born to HIV-infected women in the United Kingdom and Ireland between 1990 and 2003. Comprehensive more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  antiretroviral therapy; congenital abnormalities; HIV-1

  Geography:

  Republic of Ireland and the United Kingdom

  J Acquir Immune Defic Syndr, Vol: 42 Page: 91-4 May 2006
  C. L. Townsend; P. A. Tookey; M. Cortina-Borja; C. S. Peckham

  [Preview] [Read]

• 2.   Immunologic changes during unplanned treatment interruptions of highly active antiretroviral therapy in children with human immunodeficiency virus type 1 infection

  The aim of this study was to describe the decline of CD4 cells or percentage during unplanned treatment interruptions in HIV-infected children

  

  Abstract:

  BACKGROUND: There are few data on the decline of CD4 cells or percentage during unplanned treatment interruptions in HIV-infected children. METHODS: Data were analyzed on children undergoing interruptions of three or four drug antiretroviral therapy (HAART) in the United Kingdom and Irish Collaborative HIV Paediatric Study and from Sophia Children's Hospital, Rotterdam. Children were more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  HIV

  Geography:

  International

  Pediatr Infect Dis J, Vol: 23 Page: 446-50 May 2004
  D. M. Gibb; T. Duong; V. A. Leclezio; A. S. Walker; G. Verweel; D. T. Dunn

  [Preview] [Read]

• 3.   Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006

  The aim of this study was to describe the impact of different strategies to prevent mother-to-child transmission of HIV at a population level

  

  Abstract:

  AIM: In the United Kingdom (UK) and Ireland, avoidance of breastfeeding and alternative combinations of antiretroviral therapy regimen and mode of delivery are recommended according to maternal clinical status. The aim of this analysis was to explore the impact of different strategies to prevent mother-to-child transmission at a population level. DESIGN: Comprehensive national more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  HIV

  Geography:

  Republic of Ireland and the United Kingdom

  Aids, Vol: 22 Page: 973-81 May 2008
  C. L. Townsend; M. Cortina-Borja; C. S. Peckham; A. de Ruiter; H. Lyall; P. A. Tookey

  [Preview] [Read]

• 4.   National guidelines for the active management of HIV in pregnancy

  This article discusses national guidelines for the active management of HIV in pregnancy

  

  Abstract:

  The number of HIV positive women becoming pregnant in Ireland is increasing, with many pregnancies occurring in women from countries of high HIV prevalence. The management of such patients offers the challenge of reducing the risk of maternal-fetal transmission of HIV infection, avoiding fetal-infant toxicities, and maintaining future maternal antiretroviral options. Guidelines for the more...

  Geography:

  Republic of Ireland

  Ir Med J, Vol: 94 Page: 137-40 May 2001
  S. Clarke; K. Butler; C. Bergin; F. Lyons; G. Sheehan; M. Horgan; F. Mulcahy

  [Preview] [Read]

• 5.   Response to highly active antiretroviral therapy varies with age: the UK and Ireland Collaborative HIV Paediatric Study

  The aim of this study was to evaluate the effect of age, CD4 percentage (CD4%) and plasma HIV-1 RNA on response to highly active antiretroviral therapy in previously untreated children

  

  Abstract:

  OBJECTIVE: To evaluate the effect of age, CD4 percentage (CD4%) and plasma HIV-1 RNA on response to highly active antiretroviral therapy (HAART) in previously untreated children. DESIGN: Cohort study. METHODS: We examined the association between age at HAART initiation, and CD4 and HIV-1 RNA response using logistic and Cox regression, adjusting for sex, route of infection and pre-HAART more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  HIV-1 - antiretroviral therapy

  Geography:

  Republic of Ireland and the United Kingdom

  Aids, Vol: 18 Page: 1915-24 September 2004
  A. S. Walker; K. Doerholt; M. Sharland; D. M. Gibb

  [Preview] [Read]

• 6.   Transient viral load increases in HIV-infected children in the U.K. and Ireland: what do they mean?

  The aim of this study was to assess investigate transient increases in viral load during sustained suppression in children in the UK and Ireland Collaborative HIV Paediatric Study (CHIPS)

  

  Abstract:

  OBJECTIVES: To investigate transient increases in viral load during sustained suppression in children in the UK and Ireland Collaborative HIV Paediatric Study (CHIPS). DESIGN: Cohort of HIV-infected children from 39 centres. METHODS: Transient viraemia was defined as > or =1 detectable viral loads (> or =50 copies/ml) between two undetectable values (<50 copies/ml) <280 days apart, more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  HIV viral load

  Geography:

  Republic of Ireland and the United Kingdom

  Antivir Ther, Vol: 12 Page: 949-56 2007
  K. J. Lee; D. Shingadia; D. Pillay; A. S. Walker; A. Riordan; E. Menson; T. Duong; G. Tudor-Williams; D. M. Gibb

  [Preview] [Read]

• 7.   Trends in management and outcome of pregnancies in HIV-infected women in the UK and Ireland, 1990-2006

  The aim of this study was to examine the changing demographic profile of diagnosed HIV-infected pregnant women over time and trends in pregnancy outcome, uptake of interventions and mother-to-child transmission

  

  Abstract:

  OBJECTIVE: To describe the changing demographic profile of diagnosed HIV-infected pregnant women over time and trends in pregnancy outcome, uptake of interventions and mother-to-child transmission. DESIGN: National surveillance study. SETTING: UK and Ireland. POPULATION: Diagnosed HIV-infected pregnant women, 1990-2006. METHODS: Active surveillance of obstetric and paediatric HIV more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  HIV-infected pregnance; uptake of interventions; mother-to-child transmission of HIV

  Geography:

  Republic of Ireland and the United Kingdom

  Bjog, Vol: 115 Page: 1078-86 August 2008
  C. L. Townsend; M. Cortina-Borja; C. S. Peckham; P. A. Tookey

  [Preview] [Read]