Irish Child Health Database - Peer Reviewed Papers
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The aim of this study was to test the hypothesize that administration of adriamycin to chick embryos would cause similar anomalies to the vertebral, anorectal, cardiac, tracheoesophageal, renal, limb anomalies association seen in the Adriamycin rat mode
Abstract:
Adriamycin is an anthracycline, anti-neoplastic drug with known teratogenic effects on foetal rats in what is known as the Adriamycin rat model (ARM). This includes conditions similar to those in newborn humans, known collectively as the VACTERL association. This comprises vertebral (V), anorectal (A), cardiac (C), tracheoesophageal (TE), renal (R) and limb (L) anomalies. We designed more...
Categories:
adriamycin; VACTERL malformations - vertebral, anorectal, cardiac, tracheoesophageal, renal, limb anomalies
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 19 Page: 359-64 July 2003
A. Mortell; J. Giles; J. Bannigan; P. Puri
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The aim of this study was to determine the gene level expression of fibroblast growth factors-10 and FGF-7 in the lung of nitrofen-induced congenital diaphragmatic hernia
Abstract:
BACKGROUND/PURPOSE: Newborns with congenital diaphragmatic hernia (CDH) still have a high mortality rate, which has been attributed to pulmonary hypoplasia and pulmonary hypertension. Fibroblast growth factors (FGFs) are essential components of the gene network that regulates lung development. Recent studies suggest that the new member of FGF family, FGF-10, plays a fundamental role in more...
Categories:
gene level expression; congenital diaphragmatic hernia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 1021-4 July 2003
H. Teramoto; A. Yoneda; P. Puri
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The aim of this study was to investigate pulmonary ICAM-1 and VCAM-1 expression in congenital diaphragmatic hernia lung in rats and to determine the effect of antenatal glucocorticoid
Abstract:
Recently, increased expression of inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been reported in both humans and animal models with CDH and the decreased TNF-alpha expression in CDH lung after antenatal dexamethasone (Dex) treatment. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 are induced by several inflammatory cytokines such as more...
Categories:
antenatal glucocorticoid; congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 19 Page: 365-70 July 2003
K. Unemoto; M. Sakai; H. Shima; N. Guarino; P. Puri
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The aim of this study was to examine the hypothesis that adriamycin administration could promote upregulation of FN expression increasing gut-notochord adherence and development of abnormal ventral notochordal branching in the Adriamycin rat model
Abstract:
BACKGROUND: The VACTERL association is a spectrum of clinical conditions, including esophageal atresia (EA) and tracheoesophageal fistula (TEF), which affects approximately 1 in 5,000 live human births. The administration of intraperitoneal Adriamycin to pregnant rats reliably induces anomalies, such as EA and TEF, in their offspring, in what is known as the Adriamycin rat model (ARM). more...
Categories:
adriamycin; abnormal ventral notochordal branching
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 20 Page: 276-82 April 2004
A. Mortell; A. M. O'Donnell; S. Giles; J. Bannigan; P. Puri
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The aim of this study was to assess notochord volume sequentially from gestational days 10 to 14 to test the hypothesis that notochord hypertrophy occurs maximally soon after Adriamycin administration
Abstract:
BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the vertebral, anorectal, cardiac, tracheoesophageal, renal, and limb association. An important finding in the ARM is that Adriamycin induces abnormal notochord morphology in the region of the foregut. Having recently demonstrated notochord hypertrophy in ARM embryos, the authors designed this study to more...
Categories:
notochord volume; Adriamycin
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 403-6 February 2005
A. Mortell; J. Gillick; S. Giles; J. Bannigan; P. Puri
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The aim of this study was to determine the histochemical colocalization of cholinergic and nitrergic neurons in the porcine distal large bowel myenteric plexus from fetal to adulthood
Abstract:
PURPOSE: Cholinergic and nitrergic neurons form 2 main subpopulations of the myenteric neurons, and they have been the targets of detailed morphological investigations in bowel motility disorders. However, little is known regarding the colocalization of neurotransmitters within the same enteric neurons. The aim of this study was to determine the histochemical colocalization of more...
Categories:
histochemical colocalization of neurons; distal large bowel myenteric plexus
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 300-4 February 2007
T. Cserni; S. Paran; P. Puri
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The aim of this study was to test the hypothesized that low oxygen tension promotes lung growth in embryonic organ culture by investigating embryonic lung growth in normoxic and hypoxic conditions
Abstract:
BACKGROUND/PURPOSE: Oxygen tension is an important physiologic mediator of embryonic and fetal development. In vitro studies have demonstrated that the proper embryonic development is dependent upon low oxygen tension and even short exposure to normoxic environments (21%) can be detrimental to embryonic development. We hypothesized that low oxygen tension promotes lung growth in more...
Categories:
low oxygen tension; embryonic lung growth
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 32-5 January 2005
T. Shinkai; M. Shinkai; M. E. Pirker; S. Montedonico; P. Puri
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