Irish Child Health Database - Peer Reviewed Papers
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1. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
Activated protein C (APC) is a natural anticoagulant that plays a pivotal role in coagulation homeostasis. Severe inherited or acquired deficiency results in a clinical syndrome called purpura fulminans. In addition, APC also appears to have potent cytokine-modifying properties and is protective in animal models of sepsis. The dual functional properties of APC are particularly relevant more...
Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease
severe meningococcal septicemia
Republic of Ireland
Blood, Vol: 96 Page: 3719-24 December 2000
B. White; W. Livingstone; C. Murphy; A. Hodgson; M. Rafferty; O. P. Smith
OBJECTIVES: To determine whether the nasopharyngitis prodrome of meningococcal disease is caused by the disease itself or respiratory viral coinfection. METHODS: Case control study of children with suspected meningococcal disease. Nasal swabs and a respiratory history were obtained from suspected cases and matched controls. Molecular testing for 12 respiratory viruses was used. RESULTS: more...
Evaluation of the effectiveness of diagnosis and management of screening for hip dysplasia
Republic of Ireland and the United Kingdom
J Infect, Vol: 54 Page: 454-8 May 2007
K. A. Dunlop; P. V. Coyle; P. Jackson; C. C. Patterson; M. D. Shields