Accessibility
Legal Notices
Text Version

Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Nerve Tissue Proteins

Your search returns 3 documents

• 1.   Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD

  The aim of this study was to examine the association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with attention-deficit hyperactivity disorder

  

  Abstract:

  Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3' end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Am J Med Genet B Neuropsychiatr Genet, Vol: 121B Page: 50-4 August 2003
  A. Kirley; N. Lowe; Z. Hawi; C. Mullins; G. Daly; I. Waldman; M. McCarron; D. O'Donnell; M. Fitzgerald; M. Gill

  [Preview] [Read]

• 2.   Dopaminergic system genes in ADHD: toward a biological hypothesis

  The aim of this study was to examine issues about dopaminergic system genes in attention-deficit hyperactivity disorder and generate biological hypothesis

  

  Abstract:

  Converging evidence has implicated abnormalities of dopamine neurotransmission to the pathology of attention deficit hyperactivity disorder (ADHD). Several genetic association studies have been published, but so far, no DNA variants have been unequivocally demonstrated as contributing to ADHD susceptibility. Four dopamine related gene loci have been implicated, however: DAT 1, DRD 4, more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Neuropsychopharmacology, Vol: 27 Page: 607-19 October 2002
  A. Kirley; Z. Hawi; G. Daly; M. McCarron; C. Mullins; N. Millar; I. Waldman; M. Fitzgerald; M. Gill

  [Preview] [Read]

• 3.   Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci

  The aim of this study was to describe linkage disequilibrium mapping at DAT1, DRD5 and DBH to narrow the search for attention-deficit hyperactivity disorder susceptibility alleles at these loci

  

  Abstract:

  Abnormalities in dopaminergic neurotransmission are now accepted as factors in predisposing to ADHD. Evidence of associations between dopamine transporter gene polymorphism and ADHD was first reported by Cook et al. We confirmed the DAT1 association and also identified two additional susceptibility loci at the DRD5 and DBH. Notably, none of the associated variants at these three genes more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Mol Psychiatry, Vol: 8 Page: 299-308 March 2003
  Z. Hawi; N. Lowe; A. Kirley; F. Gruenhage; M. Nothen; T. Greenwood; J. Kelsoe; M. Fitzgerald; M. Gill

  [Preview] [Read]