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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Cell Differentiation

Your search returns 2 documents

• 1.   Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia

  The aim of this study was to investigate molecular markers for AECs-I [ICAM-1, T1alpha, aquaporin 5 ] and molecular markers for AECs-II [thyroid transcription factor-1), surfactant protein in the nitrofen-induced congenital diaphragmatic hernia lung

  

  Abstract:

  Pulmonary hypoplasia is the principal cause of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Still, relatively little is known about the mechanisms causing lung hypoplasia associated with CDH. The differentiation from alveolar epithelial cells type II (AECs-II) into alveolar epithelial cells type I (AECs-I) is one of the key processes in lung development more...

  Categories:

  molecular markers; congenital diaphragmatic hernia lung

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 23 Page: 405-10 May 2007
  H. Takayasu; N. Nakazawa; S. Montedonico; K. Sugimoto; H. Sato; P. Puri

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• 2.   Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q

  The aim of this study was to examine a metaphase comparative genomic hybridization analysis in combination with oligonucleotide technology to identify patterns of gene expression that correlate with genomic imbalances in primary neuroblastic tumours

  

  Abstract:

  A number of distinct subtypes of neuroblastoma exist with different genetic abnormalities that are predicative of outcome. Whole chromosome gains are usually associated with low stage disease and favourable outcome, whereas loss of 1p, 3p and 11q, unbalanced gain of 17q and MYCN amplification (MNA) are indicative of high stage disease and unfavourable prognosis. Although MNA and loss of more...

  International Classification:

  Neoplasms - Malignant neoplasms - neuroblastoma

  Categories:

  neuroblastic tumours

  Geography:

  Republic of Ireland

  Carcinogenesis, Vol: 25 Page: 1599-609 September 2004
  L. McArdle; M. McDermott; R. Purcell; D. Grehan; A. O'Meara; F. Breatnach; D. Catchpoole; A. C. Culhane; I. Jeffery; W. M. Gallagher; R. L. Stallings

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