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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Nuclear Family

Your search returns 10 documents

• 1.   Adverse reproductive outcomes among pregnancies of aunts and (spouses of) uncles in Irish families with neural tube defects

  The aim of this study was to examine matrilineal risk in families with neural tube defects by comparing adverse pregnancy outcomes among maternal and paternal first cousin pregnancies.

  

  Abstract:

  Adverse pregnancy outcomes may be more frequent among sibs of individuals with neural tube defects (NTDs), and transmission of risk in families with an NTD may be more frequent among maternal relatives. In a study designed to evaluate matrilineal risk for NTDs, we compared adverse pregnancy outcomes among maternal and paternal first cousin pregnancies. Pregnancy histories were obtained more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction

  Categories:

  neural tube defects

  Geography:

  Republic of Ireland

  Am J Med Genet A, Vol: 140 Page: 52-61 January 2006
  J. Byrne; S. Carolan

  [Preview] [Read]

• 2.   Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children

  The aim of this study was to describe four polymorphisms and two markers in the MAO-A gene for association with attention-deficit hyperactivity disorder

  

  Abstract:

  Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of attention deficit hyperactivity disorder (ADHD). Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. We more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Am J Med Genet B Neuropsychiatr Genet, Vol: 134B Page: 110-4 April 2005
  K. Domschke; K. Sheehan; N. Lowe; A. Kirley; C. Mullins; R. O'Sullivan; C. Freitag; T. Becker; J. Conroy; M. Fitzgerald; M. Gill; Z. Hawi

  [Preview] [Read]

• 3.   Association of early life factors and acute lymphoblastic leukaemia in childhood: historical cohort study

  The aim of this study was to examine the associations between early life factors and childhood acute lymphoblastic leukaemia

  

  Abstract:

  In a historical cohort study of all singleton live births in Northern Ireland from 1971-86 (n=434,933) associations between early life factors and childhood acute lymphoblastic leukaemia were investigated. Multivariable analyses showed a positive association between high paternal age (> or =35 years) and acute lymphoblastic leukaemia (relative risk=1.49; 95% confidence interval more...

  International Classification:

  Neoplasms-lymphoblastic leukaemia

  Categories:

  lymphoblastic leukaemia (acute)

  Geography:

  Northern Ireland

  Br J Cancer, Vol: 86 Page: 356-61 February 2002
  L. Murray; P. McCarron; K. Bailie; R. Middleton; G. Davey Smith; S. Dempsey; A. McCarthy; A. Gavin

  [Preview] [Read]

• 4.   Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population

  The aim of this study was to describe first neuronally expressed exon 1 at the dopa decarboxylase gene and two microsatellite markers flanking the gene were investigated for possible association with attention-deficit hyperactivity disorder

  

  Abstract:

  Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Both catecholamines are major neurotransmitters of the mammalian nervous system. It has been suggested that genes involved in the dopaminergic system play a primary role in predisposing to attention deficit hyperactivity disorder (ADHD). In this more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Mol Psychiatry, Vol: 6 Page: 420-4 July 2001
  Z. Hawi; D. Foley; A. Kirley; M. McCarron; M. Fitzgerald; M. Gill

  [Preview] [Read]

• 5.   No association between allelic variants of HOXA1/HOXB1 and autism

  The aim of this study was to examine the association of a variant in the HOXA1 gene and autism

  

  Abstract:

  Two recent studies have reported conflicting findings of association of a variant in the HOXA1 gene and autism. To try to resolve the conflict in findings, we conducted an association study in 78 Irish families of the reported DNA variants. We did not find statistically significant association between the variants and autism. Similarly there was no evidence of preferential transmission more...

  International Classification:

  Mental and behavioural disorders - Disorders of psychological development - autism

  Categories:

  autism

  Geography:

  Republic of Ireland

  Am J Med Genet B Neuropsychiatr Genet, Vol: 124B Page: 64-7 January 2004
  L. Gallagher; Z. Hawi; G. Kearney; M. Fitzgerald; M. Gill

  [Preview] [Read]

• 6.   No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population

  The aim of this study was to examine linkage or association between the norepinephrine transporter gene polymorphisms and attention-deficit hyperactivity disorder in the Irish population

  

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Am J Med Genet, Vol: 114 Page: 665-6 August 2002
  B. McEvoy; Z. Hawi; M. Fitzgerald; M. Gill

  [Preview] [Read]

• 7.   Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder

  The aim of this study was to examine monoaminergic candidate genes for possible genetic association with attention-deficit hyperactivity disorder

  

  Abstract:

  Family, twin, and adoption studies have demonstrated a significant genetic contribution to the etiology of attention-deficit/hyperactivity disorder (ADHD). Pharmacological, neuroimaging, and animal-model findings suggest imbalances in monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in ADHD. We have examined monoaminergic candidate genes for possible more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Am J Hum Genet, Vol: 77 Page: 958-65 December 2005
  Z. Hawi; R. Segurado; J. Conroy; K. Sheehan; N. Lowe; A. Kirley; D. Shields; M. Fitzgerald; L. Gallagher; M. Gill

  [Preview] [Read]

• 8.   Screening for new MTHFR polymorphisms and NTD risk

  This aim of this study was to screen for a new MTHFR polymorphisms and neural tube defect risk

  

  Abstract:

  The enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR) plays a key role in cellular folate metabolism. The A222V (677C->T) polymorphism is a confirmed neural tube defect (NTD) risk factor within Irish and other populations. To search for other unknown single nucleotide polymorphisms (SNPs) that might play a role in the etiology of NTDs, we examined the entire MTHFR coding region more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction

  Categories:

  polymorphisms; neural tube defect

  Geography:

  Republic of Ireland

  Am J Med Genet A, Vol: 138A Page: 99-106 October 2005
  V. B. O'Leary; J. L. Mills; A. Parle-McDermott; F. Pangilinan; A. M. Molloy; C. Cox; A. Weiler; M. Conley; P. N. Kirke; J. M. Scott; L. C. Brody

  [Preview] [Read]

• 9.   Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population

  The aim of this study was to describe the association of serotonin transporter gene and autism

  

  Abstract:

  The role of the serotonin transporter (5-HTT) in the development of neuropsychiatric disorders has been widely investigated. Two polymorphisms, an insertion/deletion in the promoter region and a 12 repeat allele in a variable nucleotide tandem repeat (VNTR) in intron 2, drive higher expression of the 5-HTT gene. Four studies have shown nominally significant excess transmission of more...

  International Classification:

  Mental and behavioural disorders - Disorders of psychological development - autism

  Categories:

  autism

  Geography:

  Republic of Ireland

  Mol Psychiatry, Vol: 9 Page: 587-93 June 2004
  J. Conroy; E. Meally; G. Kearney; M. Fitzgerald; M. Gill; L. Gallagher

  [Preview] [Read]

• 10.   Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD

  The aim of this study was to describe the association of eight single nucleotide polymorphisms in the TPH2 gene with attention-deficit hyperactivity disorder

  

  Abstract:

  Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally, the TPH gene was thought to be widely expressed, but a second form of more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland

  Mol Psychiatry, Vol: 10 Page: 944-9 October 2005
  K. Sheehan; N. Lowe; A. Kirley; C. Mullins; M. Fitzgerald; M. Gill; Z. Hawi

  [Preview] [Read]