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Irish Child Health Database - Peer Reviewed Papers

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Dexamethasone/pharmacology/therapeutic use

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1. Decreased expression of voltage-gated K+ channels in pulmonary artery smooth muscles cells in nitrofen-induced congenital diaphragmatic hernia in rats

The aim of this study was to test the hypothesize that the hyperreactivity of the newborn pulmonary vasculature in congenital diaphragmatic hernia might reflect a relatively low level of smooth muscle K(+) channel activity because of hypoxemia

Abstract:

The newborn with congenital diaphragmatic hernia (CDH) is at high risk of developing persistent pulmonary hypertension (PPH). Recently, smooth muscle K(+) channels have been implicated in hypoxic pulmonary vasoconstriction in adults. We hypothesized that the hyperreactivity of the newborn pulmonary vasculature in CDH might reflect a relatively low level of smooth muscle K(+) channel more...

Categories:

smooth muscle K(+) channel activity; hyperreactivity; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 20 Page: 192-6 March 2004
M. Sakai; K. Unemoto; V. Solari; P. Puri

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