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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » G » Growth and Development/genetics

Growth and Development/genetics

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1. Key apoptosis regulating proteins are down-regulated during postnatal tissue development

The aim of this study was to investigate if key apoptosis regulating proteins are down-regulated during postnatal tissue development

Abstract:

The intrinsic apoptotic pathway is essential for murine development. We have previously shown that key mediators of this pathway, such as Bim, Apaf-1 and caspase-3, are down-regulated during the postnatal development of the retina. In this study, we demonstrate that this expression pattern is a feature of other distinct tissues such as the brain, heart and skeletal muscle. Caspase-9 more...

Categories:

apoptosis regulating proteins; postnatal tissue development

Geography:

Republic of Ireland

Int J Dev Biol, Vol: 51 Page: 415-23 2007
S. D. Madden; M. Donovan; T. G. Cotter

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