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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » P » Pulmonary Surfactant-Associated Protein A

Pulmonary Surfactant-Associated Protein A

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1. Effect of hyperoxia on surfactant protein gene expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats

The aim of this study was to investigate SP mRNA expression in hypoplastic congenital diaphragmatic hernia lung in rats during mechanical ventilation in order to determine the effect of O2 on SP synthesis in congenital diaphragmatic hernia

Abstract:

The hypoplastic lung in congenital diaphragmatic hernia (CDH) has both a quantitative and qualitative reduction in surfactant. Recently, the role of oxygen (O2) as a regulator of pulmonary surfactant-associated protein (SP) gene expression has been reported. The mRNA level of SP has been demonstrated to be increased in the lungs of animals exposed to hyperoxia. The aim of this study was more...

Categories:

SP mRNA expression; congenital diaphragmatic hernia lung

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 16 Page: 473-7 2000
H. Shima; N. Guarino; P. Puri

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