Irish Child Health Database - Peer Reviewed Papers
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The aim of this study was to determine the expression of Ag-II receptor subtypes and TGF-beta1 in the hypoplastic heart of nitrofen-induced congenital diaphragmatic hernia
Abstract:
The renin-angitensin system (RAS) plays an important role as a growth factor in cardiac development. Angiotensin converting enzyme is involved in converting angiotensin I to angiotensin II (Ag-II). The effects of Ag-II are mediated by two primary receptors, type 1 (AT1) and type 2 (AT2). Ag-II stimulates transforming growth factor-beta1(TGF-beta1) and acts as a potent stimulant of more...
Categories:
hypoplastic heart; congenital diaphragmatic hernia
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 21 Page: 148-52 March 2005
H. Teramoto; M. Shinkai; P. Puri
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The aim of this study was to investigate mRNA expression of ET-1, eNOS, and CGRP in congenital diaphragmatic hernia lung in the perinatal period
Abstract:
The high mortality in patients with congenital diaphragmatic hernia (CDH) has been attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PPH). Endothelin-1 (ET-1), nitric oxide (NO), and calcitonin gene-related peptide (CGRP) have been reported to be important vasoactive mediators in the perinatal pulmonary circulation. The exact mechanism by which these vasoactive more...
Categories:
mRNA expression; congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 21 Page: 143-7 March 2005
T. Shinkai; H. Shima; V. Solari; P. Puri
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