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The aim of this study was to examine neonatal human autologous dendritic cells pulsed with recombinant protein antigen prime the generation of non-polarized CD4 T-cell effectors
Abstract:
The functional capability of human neonatal CD4 T cells to respond to vaccine antigens is frequently described as Th2 biased, but whether this is due to defective T-cell or antigen-presenting cell (APC) function is unclear. In this study, we used purified T cells and autologous monocyte-derived dendritic cells (MDDCs) as APCs to model primary and secondary neonatal CD4 T-cell responses more...
International Classification:
Other - autologous dendritic cells
Categories:
neonatal human autologous dendritic cells
Geography:
Republic of Ireland
Int Immunol,
Vol: 19 Page: 703-12 June 2007
N. C. Matthews; U. F. Power; D. J. Reen
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