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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » A » Abnormalities, Multiple/ embryology

Abnormalities, Multiple/ embryology

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1. Altered renin-angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia

The aim of this study was to test the hypothesize that abnormal expression of renin-angiotensin system components may be responsible for renal hypoplasia in congenital diaphragmatic hernia

Abstract:

The association between renal hypoplasia and pulmonary hypoplasia in congenital diaphragmatic hernia (CDH) has become recently appreciated. However, the underlying mechanisms responsible for this association are still unknown. Renin-angiotensin system (RAS) plays an important role in renal and somatic growth, angiogenesis and reproduction. We hypothesized that abnormal expression of RAS more...

Categories:

renin-angiotensin system; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 22 Page: 57-60 January 2006
B. Chertin; N. Nakazawa; S. Montedonico; H. Shima; P. Puri

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