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Abnormalities, Drug-Induced/ pathology
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The aim of this study was to investigate the hypothesise of increased cell death in adriamycin-exposed embryos
Abstract:
The adriamycin rat model (ARM) exhibits many features of the VACTERL association. Adriamycin is a cytotoxic drug used in cancer chemotherapy. Although its exact mode of action is not clear, it is presumed to have a similar cytotoxic role in the developing embryo. Lysotracker red (LT) is a dye that stains phagolysosomes and apoptotic bodies and allows entire rodent embryos to be stained more...
Categories:
adriamycin-exposed embryos; increased cell death;
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 18 Page: 576-80 October 2002
J. Gillick; S. Giles; J. Bannigan; P. Puri
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