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Irish Child Health Database - Peer Reviewed Papers

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  • Outcome of infants born to hepatitis C infected women

    Published in:

    Ir J Med Sci, Vol: 170, Page: 103-6; discussion 92-3

    Publication Date:

    2001 Apr-Jun

    Aims & Objectives:

    The aim of this study was to examine outcomes of infants born to Hepatitis C virus infected women, to characterise epidemiology and to design an appropriate infant monitoring schedule


    BACKGROUND: Hepatitis C virus (HCV) can be transmitted vertically from mother to infant, either late in pregnancy or at delivery. AIMS: To determine the outcome of infants born to HCV infected women, to characterise epidemiology and to design an appropriate infant monitoring schedule. METHODS: Three hundred and fourteen infants, born to 296 HCV positive women between 1994 and 1999 were monitored for a median of 18 months (range 1-52). RESULTS: Forty per cent of infants were small for age and 46% had neonatal abstinence syndrome (NAS). Of 173 infants of defined status, 11 were infected (vertical transmission rate [VTR] 6.4%, 95% CI 2.8-10). Infected infants were diagnosed at a median of three months (range 0.5-10). Liver transaminases elevation was documented in 8% of uninfected infants. A negative HCV PCR test before one month of age did not exclude infection but all infected patients had detectable HCV RNA when next tested (range 2-10 months). CONCLUSIONS: 94% of infants born to HCV antibody positive women are not HIV infected. Liver transaminase elevation in exposed infants is not always indicative of infection. A minimum monitoring schedule of testing (PCR and antibody) at six to eight weeks, six and 18 months allows early diagnosis while detecting late seroconversions.


    C. M. Healy; M. T. Cafferkey; A. Conroy; S. Dooley; W. W. Hall; M. Beckett; T. A. Clarke; M. J. White; W. A. Gorman; K. M. Butler

    Study Type:

    Study Papers » Case Study » Descriptive Studies - Without a comparision


    hepatitis C

    International Classification:

    Certain infectious and parasitic diseases - Viral hepatitis - hepatitis C



    Republic of Ireland (Republic of Ireland)