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Irish Child Health Database - Peer Reviewed Papers

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You are here: Irish Child Health Database » Study Papers » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures » Epidemiology - descriptive, incidence, prevalence and/or trends
  • Clinical and immunological risk factors associated with Haemophilus influenzae type b conjugate vaccine failure in childhood

    Published in:

    Clin Infect Dis, Vol: 31, Page: 973-80

    Publication Date:

    October 2000

    Aims & Objectives:

    The aim of this study was to examine the clinical and immunological risk factors associated with Haemophilus influenzae type b conjugate vaccine failure in childhood

    Abstract:

    Haemophilus influenzae type b (Hib) conjugate vaccines have proved extremely efficacious in healthy children. True Hib vaccine failures are rare. Hib conjugate vaccines were introduced for routine immunization in the United Kingdom and the Republic of Ireland in 1992. Coincident with this, active prospective and national surveillance via pediatricians, microbiologists, and public health physicians was commenced to assess the clinical and immunological factors associated with vaccine failure. During the 6 years of the study, 115 children with true vaccine failure were reported. Of the children who were vaccinated before 12 months of age, a clinical risk factor was detected in 20%, an immunological deficiency was detected in 30%, and one or both were detected in 44%. Children who were vaccinated after 12 months of age were more likely to have one or both factors (67%). Thirty percent (33 of 105) of children with true vaccine failure had a low Hib antibody response (concentration, <1.0 microg/mL) after disease, but the majority then responded to a further dose of Hib vaccine. Children who develop Hib disease despite vaccination deserve further clinical and immunological evaluation.

    Authors:

    P. T. Heath; R. Booy; H. Griffiths; E. Clutterbuck; H. J. Azzopardi; M. P. Slack; J. Fogarty; A. C. Moloney; E. R. Moxon

    Study Type:

    Study Papers » Epidemiology - descriptive, incidence, prevalence and/or trends » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures

    Categories:

    Haemophilus influenzae type b

    International Classification:

    Bacterium - Haemophilus influenzae type b

    Keywords:


    Geography:

    Republic of Ireland and the United Kingdom (UK & Ireland)