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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

• Special article: chronic granulomatous disease in the United Kingdom and Ireland: a comprehensive national patient-based registry

  Published in:

  Clin Exp Immunol, Vol: 152, Page: 211-8

  Publication Date:

  May 2008

  Aims & Objectives:

  The aim of this study was to examine chronic granulomatous disease in the United Kingdom and Ireland

  Abstract:

  There are no epidemiological studies from the British Isles of chronic granulomatous disease, characterized by recurrent, life-threatening bacterial and fungal infections and inflammatory sequelae. Patients were enrolled in a national registry and medical records were analysed. Of 94 subjects, 69 had X-linked disease, 16 had autosomal recessive disease and nine were unknown. Prevalence was 7.5/million for 1990-99 and 8.5/million for 1980-89. Suppurative adenitis, abscesses and pneumonia presented commonly. Twenty-three of 30 patients who underwent high resolution computerized tomography had chronic respiratory disease. Inflammatory sequelae included bowel stricture and urogenital tract granulomata. Growth failure was common; 75% of those measured were below the population mean. All patients received prophylactic antibiotics and 93% anti-fungal prophylaxis. Interferon gamma was used to treat infection, but rarely as prophylaxis. Despite prophylaxis, estimated survival was 88% at 10 years but 55% at age 30 years. Morbidity remains significant, severe infectious complications common. Curative treatments including stem cell transplantation should be considered for patients with frequent or serious complications.

  Authors:

  L. B. Jones; P. McGrogan; T. J. Flood; A. R. Gennery; L. Morton; A. Thrasher; D. Goldblatt; L. Parker; A. J. Cant

  Study Type:

  Study Papers » Case Study » Descriptive Studies - Without a comparision

  Categories:

  Chronic granulomatous disease

  International Classification:

  Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - Other diseases of blood and blood-forming organs - Chronic granulomatous disease

  Keywords:

  • Adolescent
  • Adult
  • Aspergillosis/complications/epidemiology
  • Child
  • Child, Preschool
  • Epidemiologic Methods
  • Female
  • Granulomatous Disease, Chronic/complications/ epidemiology
  • Great Britain/epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Ireland/epidemiology
  • Male
  • Middle Aged
  • Opportunistic Infections/complications/epidemiology
  • Respiratory Tract Infections/complications/epidemiology
  • Staphylococcal Infections/complications/epidemiology

  
  

  Geography:

  Republic of Ireland and the United Kingdom (UK & Ireland)