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Irish Child Health Database - Peer Reviewed Papers

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  • Anti-epileptic drugs in pregnancy: current safety and other issues

    Published in:

    Expert Opin Pharmacother, Vol: 4, Page: 445-56

    Publication Date:

    April 2003

    Aims & Objectives:

    This article discusses the need for women with epilepsy to both take their medication but also consider the effect of anti-epileptic drugs on their developing fetus


    Women with epilepsy of child-bearing years have their own considerations, which must be taken into account if management of their epilepsy is to be optimised. The main issues to consider include the effects of: female hormones on seizure control, anti-epileptic drugs (AEDs) on hormonal methods of contraception, epilepsy and AEDs on fertility, epilepsy and AEDs on pregnancy itself, pregnancy on AEDs and seizure control and epilepsy, seizures and AEDs on the developing embryo/fetus. Whereas previous studies have concentrated on the increased risk of major congenital malformations from prenatal AED exposure, the effects on cognitive and behavioural development are increasingly being explored. This article looks at the evidence currently available for all of the above issues, taking into account the increased number of AEDs which are now available.


    J. I. Morrow; J. J. Craig

    Study Type:

    Non Study Papers » Discussion paper, review, commentary, letter »



    Northern Ireland (Northern Ireland)