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Irish Child Health Database - Peer Reviewed Papers

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  • Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies

    Published in:

    Arch Dis Child Fetal Neonatal Ed, Vol: 89, Page: F61-4

    Publication Date:

    January 2004

    Aims & Objectives:

    The aim of this study was to determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life

    Abstract:

    OBJECTIVE: To determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life. DESIGN: Prospective observational study. SETTING: Regional neonatal intensive care unit. PATIENTS: Thirty five ventilated preterm babies < 33 weeks gestation, seven of whom were born after chorioamnionitis, which was diagnosed histologically as the presence of inflammatory cells in the chorioamnionic plate. METHODS: MMP-8 was measured by enzyme linked immunosorbent assay (ELISA) in 90 serial BAL samples taken during the first six postnatal days. The median MMP-8 concentration for each baby was calculated. RESULTS: Median MMP-8 concentrations were higher in the chorioamnionitis group than in those without (43 v 5 ng/ml). Partial or complete courses of antenatal corticosteroids had no effect on MMP-8 concentrations. CONCLUSIONS: Higher concentrations of MMP-8 are found in BAL fluid from preterm babies from pregnancies complicated by chorioamnionitis. This type I collagenase may contribute to the lung injury that occurs in some babies with respiratory distress syndrome.

    Authors:

    A. E. Curley; D. G. Sweet; K. J. MacMahon; C. M. O'Connor; H. L. Halliday

    Study Type:

    Study Papers » Case Study » Descriptive Studies - Without a comparision

    Categories:

    chorioamnionitis;

    International Classification:

    Pregnancy, childbirth and the puerperium - chorioamnionitis

    Keywords:


    Geography:

    Northern Ireland (Northern Ireland)