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Irish Child Health Database - Peer Reviewed Papers

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  • Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae

    Published in:

    Infect Immun, Vol: 69, Page: 2708-13

    Publication Date:

    April 2001

    Aims & Objectives:

    The aim of this study was to investigate whether molecular mimicry by Helicobacter mustelae causes autoantibodies in infected ferrets

    Abstract:

    Infection with Helicobacter pylori has been associated with induction of autoantibodies that cross-react with the gastric mucosa. There have been discordant reports as to whether or not these autoantibodies arise due to molecular mimicry between H. pylori and host cell antigens on parietal cells. In this study, we investigated whether molecular mimicry by H. mustelae causes autoantibodies in infected ferrets. Serum from H. mustelae-infected ferrets reacted with parietal cells in the ferret gastric mucosa but not with duodenal or colonic mucosa. These sera did not react with the blood group A epitope on erythrocytes or H. mustelae lipopolysaccharide, and absorption with H. mustelae whole cells or red blood cells did not remove autoantibodies. In conclusion, ferrets naturally infected with H. mustelae generate antibodies that react with parietal cells, but these autoantibodies are not due to molecular mimicry.

    Authors:

    T. O. Croinin; M. Clyne; B. J. Appelmelk; B. Drumm

    Study Type:

    Study Papers » Animal Study » Papers reporting secondary research

    Categories:

    Helicobacter mustelae; autoantibodies

    Keywords:


    Geography:

    Republic of Ireland (Republic of Ireland)