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Irish Child Health Database - Peer Reviewed Papers

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You are here: Irish Child Health Database » Study Papers » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures » Epidemiology - descriptive, incidence, prevalence and/or trends
  • National enhanced surveillance of meningococcal disease in England, Wales and Northern Ireland, January 1999-June 2001

    Published in:

    Epidemiol Infect, Vol: 129, Page: 459-70

    Publication Date:

    December 2002

    Aims & Objectives:

    The aim of this study was to examine the incidence meningococcal disease and the enhanced surveillance of meningococcal disease (ESMD) which was implemented nationally across ten regions of England, Wales and Northern Ireland from 1 January 1999.

    Abstract:

    Enhanced surveillance of meningococcal disease (ESMD) was implemented nationally across ten regions of England, Wales and Northern Ireland from 1 January 1999. It aims to deliver more sensitive surveillance than laboratory reporting by including clinically diagnosed but laboratory unconfirmed cases. Consultants in Communicable Disease Control (CsCDC) report all clinically diagnosed cases of meningococcal disease (MD) to the Regional Epidemiologist in the relevant regional unit of the Public Health Laboratory Service (PHLS) Communicable Disease Surveillance Centre (CDSC). These reports are reconciled with laboratory data from the PHLS Meningococcal Reference Unit and then forwarded to the national CDSC where further reconciliation with laboratory data takes place. In addition, CsCDC are asked to report any clusters of MD that occur. Between 1 January 1999 and 30 June 2001, 12,074 cases of MD were ascertained through ESMD. The majority (57%) were laboratory confirmed. The estimated incidence of MD fell between 1999 and 2001 from 9.2 to 8.0 per 100,000 population. Of laboratory confirmed cases, the number of cases of serogroups B and W135 increased and of serogroup C and of ungrouped meningococcal infection decreased. Variation between regions was considerable and deserves further investigation. Of 11,522 cases with a reported clinical diagnosis, 53.6% were diagnosed as septicaemia, 32.6% as meningitis, 12.5% as both septicaemia and meningitis, and 13% had other invasive MD. Between 1 January 1999 and 30 June 2001 698 deaths were reported, an overall case fatality rate (CFR) of 5.8%; 567 deaths were in confirmed cases and 131 probable (CFR 8.2% and 2.5%, respectively). CFR was higher in serogroup C (13.5%) than B (5.8%). No peak in serogroup C meningococcal infection occurred in the winter of 2000/1 and no clusters of serogroup C meningococcal infection were reported in the first half of 2001. ESMD provides information about the epidemiology of MD that is more complete than statutory notification and laboratory surveillance and is useful for evaluating the impact of the meningococcal serogroup C vaccination programme and of the other non-vaccine preventable serogroups.

    Authors:

    M. Shigematsu; K. L. Davison; A. Charlett; N. S. Crowcroft

    Study Type:

    Study Papers » Epidemiology - descriptive, incidence, prevalence and/or trends » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures

    Categories:

    meningococcal disease

    International Classification:

    Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease

    Keywords:


    Geography:

    the United Kingdom (England, Wales and Northern Ireland)