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Irish Child Health Database - Peer Reviewed Papers

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You are here: Irish Child Health Database » Study Papers » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures » Epidemiology - descriptive, incidence, prevalence and/or trends
  • Human seroprevalence to Coxiella burnetii (Q fever) in Northern Ireland

    Published in:

    Zoonoses Public Health, Vol: 55, Page: 189-94

    Publication Date:

    May 2008

    Aims & Objectives:

    The aim of this study was to examine the distribution and determinants of C. Burnetii past infection

    Abstract:

    Despite the widespread prevalence of infection with Coxiella burnetii, there have been few large population-based studies examining the epidemiology of this infection. The aim of this study was to examine the distribution and determinants of C. burnetii past infection in Northern Ireland (NI). Coxiella burnetii phase II specific IgG antibodies were measured by enzyme-linked immunosorbent assay in stored serum from 2,394 randomly selected subjects, aged 12-64, who had participated in population-based surveys of cardiovascular risk factors performed in 1986 and 1987. The overall prevalence of C. burnetii antibody positivity was 12.8%. The prevalence of sero-positivity was slightly higher in males than that in females (14.3% versus 11.2%, P = 0.02). Sero-positivity was low in children (<10%), increasing to 19.5% and 16.4% in males and females, respectively, in the 25-34 age group and subsequently remaining fairly steady with increasing age. Sero-positivity among farmers, at 48.8%, was significantly higher than the general population. More sero-positive than sero-negative women had a history of a miscarriage or still-birth (19.5% versus 9.8%, P < 0.001). In conclusion, this study demonstrated a high prevalence of evidence of past C. burnetii infection in NI. Associations between past C. burnetii infection and age, sex, social class, occupation and reproductive history were seen. We estimate that 20% of Q fever infections in NI occur in farmers.

    Authors:

    C. McCaughey; J. McKenna; C. McKenna; P. V. Coyle; H. J. O'Neill; D. E. Wyatt; B. Smyth; L. J. Murray

    Study Type:

    Study Papers » Epidemiology - descriptive, incidence, prevalence and/or trends » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures

    Categories:

    C. burnetii

    International Classification:

    Bacterium - C. Burnetii

    Keywords:


    Geography:

    Northern Ireland (Northern Ireland)