Skip Navigation, or press ALT and K together and then press enter.Welcome to the OMC website. This site has been developed for both the visually impaired and non visually impaired. If you would like to use the visually impaired version of this site please go to omc.gov.ie/viewtxt.asp, or press ALT and I together and then press enter

Irish Child Health Database - Peer Reviewed Papers

Database Search


  • Corticosteroids in the prevention and management of bronchopulmonary dysplasia

    Published in:

    Semin Neonatol, Vol: 8, Page: 83-91

    Publication Date:

    February 2003

    Aims & Objectives:

    This article discusses evidence-based guidelines for postnatal steroid therapy in the management of chronic lung disease.

    Abstract:

    Corticosteroids were first prescribed for preterm neonates to treat respiratory distress syndrome, but they were found to have no beneficial effect in this disorder. About 20 years ago, dexamethasone was first used to treat infants with bronchopulmonary dysplasia who were ventilator dependent after the age of 3 weeks. There were short-term benefits, with an improvement in lung function and a facilitation of endotracheal extubation. During the 1990s, corticosteroid treatment, mainly with dexamethasone in relatively high doses, became very common in neonatal intensive care units. Towards the end of the decade, however, follow-up studies provided evidence of abnormal neurodevelopment, especially in infants treated early (<4 days) with dexamethasone. The precise cause of these neurodevelopmental problems is unclear, but until further evidence has been obtained, the early use of dexamethasone cannot be recommended for preterm infants. This review attempts to provide evidence-based guidelines for postnatal steroid therapy in the management of chronic lung disease.

    Authors:

    D. G. Grier; H. L. Halliday

    Study Type:

    Non Study Papers » Discussion paper, review, commentary, letter »

    Keywords:


    Geography:

    Northern Ireland (Northern Ireland)