Skip Navigation, or press ALT and K together and then press enter.Welcome to the OMC website. This site has been developed for both the visually impaired and non visually impaired. If you would like to use the visually impaired version of this site please go to omc.gov.ie/viewtxt.asp, or press ALT and I together and then press enter

Irish Child Health Database - Peer Reviewed Papers

Database Search


You are here: Irish Child Health Database » Study Papers » Descriptive Studies - Studies with a health technology dimension » A randomized controlled trial
  • High frequency oscillatory ventilation was not more effective than conventional ventilation in preterm infants

    Published in:

    Evidence-Based Nursing, Vol: 6, Page: 41-41

    Publication Date:

    2003

    Aims & Objectives:

    The aim of this study was to assess high frequency oscillatory ventilation reduce death and chronic lung disease when compared with conventional ventilation in preterm infants who are 23-28 weeks gestational age

    Abstract:

    QUESTION: In preterm infants who are 23-28 weeks gestational age, does high frequency oscillatory ventilation (HFOV) reduce death and chronic lung disease when compared with conventional ventilation (CV)? Design: Randomised (unclear allocation concealment), unblinded, controlled trial with 8-13 weeks of follow up for the primary outcome. Setting: 25 centres: 22 in the UK and 1 each in Australia, Ireland, and Singapore. Patients: 870 infants were randomised before or just after delivery. 804 surviving infants who required endotracheal intubation from birth and ongoing intensive care were included. Exclusion criteria were transfer to another hospital for intensive care shortly after birth or major congenital abnormality. 797 infants (92%) (mean gestational age 26.5 wks, 54% boys) were included in the analysis. Intervention: After stratification for gestational age and centre, infants were allocated to HFOV (n=400) or CV (n=397) within 1 hour of birth. HFOV was given by 1 of 3 high frequency oscillator models. Ventilation began at a mean airway pressure of 6-8 cm of water and a frequency of 10 Hz; the amplitude was increased until the infant's chest was seen to be "bouncing". CV was given by a time cycled, pressure limited ventilator, starting at a rate of 60 breaths per minute and an inspiratory time of 0.4 seconds. Settings were subsequently adjusted to maintain a partial pressure of oxygen of 49-75 mm Hg and a partial pressure of carbon dioxide of 34-53 mm Hg. Main outcome measure: Composite endpoint of death or chronic lung disease (defined as dependence on supplemental oxygen at 36 weeks gestational age. Main results: Analysis was by intention to treat. HFOV did not differ from CV for the composite endpoint of death or chronic lung disease, death, or chronic lung disease (table). Conclusion: In preterm infants who were 23-28 weeks gestational age, high frequency oscillatory ventilation did not reduce combined death and chronic lung disease more than conventional ventilation.

    Authors:

    C. Cheng; P. Shah

    Study Type:

    Study Papers » A randomized controlled trial » Descriptive Studies - Studies with a health technology dimension

    Notes:

    Accession Number: 2004040749. Language: English. Entry Date: 20040305. Publication Type: journal article; abstract; commentary; tables/charts. Original Study: Johnson AH, Peacock JL, Greenough A, Marlow N, Limb ES, Marston L, et al. High-frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity. N ENGL J MED 2002 Aug 29; 347(9): 633-42 (research) . Journal Subset: Core Nursing; Nursing; Online/Print; UK & Ireland. Special Interest: Evidence-Based Practice; Pediatric Care. No. of Refs: 3 ref. NLM UID: 9815947. 1367-6539 PMID: 12710416

    Categories:

    ventilation in preterm infants

    International Classification:

    Evaluation of the effectiveness of two ventilation methods

    Keywords:


    Geography:

    International (UK, Australia, Ireland, Singapore)