Skip Navigation, or press ALT and K together and then press enter.Welcome to the OMC website. This site has been developed for both the visually impaired and non visually impaired. If you would like to use the visually impaired version of this site please go to omc.gov.ie/viewtxt.asp, or press ALT and I together and then press enter

Irish Child Health Database - Peer Reviewed Papers

Database Search


You are here: Irish Child Health Database » Study Papers » Descriptive Studies - Without a comparision » Case Study
  • Ocular axial length in homocystinuria patients with and without ocular changes: effects of early treatment and biochemical control

    Published in:

    J Aapos, Vol: 8, Page: 254-8

    Publication Date:

    June 2004

    Aims & Objectives:

    The aim of this study was to examine whether myopia in homocystinuria could be due to increased ocular axial length

    Abstract:

    PURPOSE: To establish whether myopia in homocystinuria could be due to increased ocular axial length. METHODS: Measurement of ocular axial length by A-scan ultrasound in eyes of homocystinuria patients. RESULTS: Patients were divided into three groups. Group I, with no ocular pathology (28 eyes), had mean refractive error of -0.25 D (spherical equivalent) and mean axial length of 23.4 mm +/- 0.9 (+/-1 standard deviation) mm. Group II, with phacodonesis or lens subluxation (12 eyes), had mean refractive error of -10.7 D and mean axial length of 23.8 mm +/-1.9 mm. Patients with phacodonesis had simple myopia whereas those with lens subluxation had marked myopic astigmatism. Group III included patients with complete lens dislocation in at least one eye (12 eyes) and were optically aphakic with a mean refractive error of +12.9 D and mean axial length of 24.9 mm +/- 0.9 mm. All Group I patients had good long-term metabolic control while those in Groups II and III did not. Group III eyes had significantly longer mean axial length than Group I (P =.0018) or normal eyes (P =.0163). There was no statistical difference in mean axial length between Group I and normal eyes. CONCLUSIONS: Ocular axial length is significantly increased in individuals with homocystinuria and lens dislocation. Increased axial length is a complication that has not been previously described in homocystinuria and may be preventable with early treatment and good biochemical control.

    Authors:

    A. Mulvihill; M. O'Keeffe; S. Yap; E. Naughten; P. Howard; B. Lanigan

    Study Type:

    Study Papers » Case Study » Descriptive Studies - Without a comparision

    Categories:

    myopia; homocystinuria

    International Classification:

    Diseases of the eye and adnex - Disorders of ocular muscles, binocular movement, accommodation and refraction - myopia

    Keywords:


    Geography:

    Republic of Ireland (Dublin (USA))