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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

• Ocular axial length in homocystinuria patients with and without ocular changes: effects of early treatment and biochemical control

  Published in:

  J Aapos, Vol: 8, Page: 254-8

  Publication Date:

  June 2004

  Aims & Objectives:

  The aim of this study was to examine whether myopia in homocystinuria could be due to increased ocular axial length

  Abstract:

  PURPOSE: To establish whether myopia in homocystinuria could be due to increased ocular axial length. METHODS: Measurement of ocular axial length by A-scan ultrasound in eyes of homocystinuria patients. RESULTS: Patients were divided into three groups. Group I, with no ocular pathology (28 eyes), had mean refractive error of -0.25 D (spherical equivalent) and mean axial length of 23.4 mm +/- 0.9 (+/-1 standard deviation) mm. Group II, with phacodonesis or lens subluxation (12 eyes), had mean refractive error of -10.7 D and mean axial length of 23.8 mm +/-1.9 mm. Patients with phacodonesis had simple myopia whereas those with lens subluxation had marked myopic astigmatism. Group III included patients with complete lens dislocation in at least one eye (12 eyes) and were optically aphakic with a mean refractive error of +12.9 D and mean axial length of 24.9 mm +/- 0.9 mm. All Group I patients had good long-term metabolic control while those in Groups II and III did not. Group III eyes had significantly longer mean axial length than Group I (P =.0018) or normal eyes (P =.0163). There was no statistical difference in mean axial length between Group I and normal eyes. CONCLUSIONS: Ocular axial length is significantly increased in individuals with homocystinuria and lens dislocation. Increased axial length is a complication that has not been previously described in homocystinuria and may be preventable with early treatment and good biochemical control.

  Authors:

  A. Mulvihill; M. O'Keeffe; S. Yap; E. Naughten; P. Howard; B. Lanigan

  Study Type:

  Study Papers » Case Study » Descriptive Studies - Without a comparision

  Categories:

  myopia; homocystinuria

  International Classification:

  Diseases of the eye and adnex - Disorders of ocular muscles, binocular movement, accommodation and refraction - myopia

  Keywords:

  • Adolescent
  • Adult
  • Astigmatism/ etiology/physiopathology
  • Body Weights and Measures
  • Child
  • Cystathionine beta-Synthase/deficiency
  • Diet, Protein-Restricted
  • Eye/growth & development/ pathology
  • Female
  • Homocystine/blood
  • Homocystinuria/ complications/physiopathology/ therapy
  • Humans
  • Lens Subluxation/etiology/therapy
  • Male
  • Myopia/ etiology/physiopathology
  • Pyridoxine/ therapeutic use
  • Visual Acuity

  
  

  Geography:

  Republic of Ireland (Dublin (USA))